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1
Linde, K.; Ramirez, G.; Mulrow, C.D.; Pauls, A.; Weidenhammer, W.; Melchart, D.
St John's wort for depression - an overview and meta-analysis of randomised clinical trials
BMJ, 1996, 313, 253-258
St John's wort for depression - an overview and meta-analysis of randomised clinical trials
BMJ, 1996, 313, 253-258
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
2
Schulz, V.
Johanniskraut als pflanzliches Antidepressivum
Loew, D., Rietbrock, N.(Hrsg.): Phytopharmaka in Forschung und klinischer Anwendung, 1995, 159-176
Johanniskraut als pflanzliches Antidepressivum
Loew, D., Rietbrock, N.(Hrsg.): Phytopharmaka in Forschung und klinischer Anwendung, 1995, 159-176
Depression, Research, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review, Theory
3
Schmidt, U.; Harrer, G.; Kuhn, U.; Biller, A.
Äquivalenzvergleich: Johanniskrautextrakt LoHyp-57 vs. Fluoexetin-HCI
Beitrag des Symposiums "Phytopharmaka 2000", Bonn Nov. 1998
Z Phytother, 1999, 20(2), 89-90
Äquivalenzvergleich: Johanniskrautextrakt LoHyp-57 vs. Fluoexetin-HCI
Beitrag des Symposiums "Phytopharmaka 2000", Bonn Nov. 1998
Z Phytother, 1999, 20(2), 89-90
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases
4
Mück-Weymann, M.; Lukesch, J.; Kaltwasser, A.; Zeller, K.; Joraschky, P.
Verändert Johanniskrautextrakt bei depressiven Patienten autonome Funktionen?
Beitrag des Symposiums "Phytopharmaka 2000", Bonn Nov. 1998
Z Phytother, 1999, 20(2), 91-92
Verändert Johanniskrautextrakt bei depressiven Patienten autonome Funktionen?
Beitrag des Symposiums "Phytopharmaka 2000", Bonn Nov. 1998
Z Phytother, 1999, 20(2), 91-92
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases
5
Linde, K.; Mulrow, C.D.
St John's wort for depression
Cochrane Database Syst Rev, 2000, 1(CD000448), 1-17
St John's wort for depression
Cochrane Database Syst Rev, 2000, 1(CD000448), 1-17
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
6
Whiskey, E.; Werneke, U.; Taylor, D.
A systematic review and meta-analysis of Hypericum perforatum in depression
A comprehensive clinical review
Int Clin Psychopharmacol, 2001, 16, 239-252
A systematic review and meta-analysis of Hypericum perforatum in depression
A comprehensive clinical review
Int Clin Psychopharmacol, 2001, 16, 239-252
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Systematic review
7
Linde, K.
Extracts of Hypericum perforatum for depression
A systematic review of randomized controlled trials
Chrubasik, S. et al. (eds.): Herbal medicinal products for the treatment of pain, 2000, 154-163
Extracts of Hypericum perforatum for depression
A systematic review of randomized controlled trials
Chrubasik, S. et al. (eds.): Herbal medicinal products for the treatment of pain, 2000, 154-163
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
8
Zeller, K.
Once daily administration of Hypericum extract (STW 3): a convenient treatment
Chrubasik, S. et al. (eds.): Herbal medicinal products for the treatment of pain, 2000, 164-168
Once daily administration of Hypericum extract (STW 3): a convenient treatment
Chrubasik, S. et al. (eds.): Herbal medicinal products for the treatment of pain, 2000, 164-168
Depression, St John's wort, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases
9
Kasper, S.; Dienel, A.
Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients
A meta-analysis of data from three randomized, placebo-controlled trials
Psychopharmacol, 2002, 164, 301-308
Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients
A meta-analysis of data from three randomized, placebo-controlled trials
Psychopharmacol, 2002, 164, 301-308
Chemistry, Cluster, Depression, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Physical Chemistry, Phytomedicine, Mental diseases
10
Hammerness, P.; Brasch, E.; Ulbricht, E.; Barrette, E.P.; Foppa, I.; Basch, S.; Bent, S.; Boon, H.; Ernst, E.
St. John's wort: A systematic review of adverse effects and drug interactions for the consultation psychiatrist
Psychosomatics, 2003, 44(4), 271-282
St. John's wort: A systematic review of adverse effects and drug interactions for the consultation psychiatrist
Psychosomatics, 2003, 44(4), 271-282
Anxiety, Arzneimittelwechselwirkung, Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review, Adverse effect
11
Röder, C.; Schaefer, M.; Leucht, S.
Meta-Analyse zu Wirksamkeit und Verträglichkeit der Behandlung der leichten und mittelschweren Depression mit Johanniskraut
Fortschr Neurol Psychiatr, 2004, 72(6), 330-343
Meta-Analyse zu Wirksamkeit und Verträglichkeit der Behandlung der leichten und mittelschweren Depression mit Johanniskraut
Fortschr Neurol Psychiatr, 2004, 72(6), 330-343
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Adverse effect
12
Linde, K.; Knüppel, L.
Large-scale observational studies of hypericum extracts in patients with depressive disorders
A systematic review
Phytomed, 2005, 12(1-2), 148-157
Large-scale observational studies of hypericum extracts in patients with depressive disorders
A systematic review
Phytomed, 2005, 12(1-2), 148-157
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
13
Werneke, U.; Horn, O.; Taylor, D.M.
How effective is St John's wort?
The evidence revisited
J Clin Psych, 2004, 65, 611-617
How effective is St John's wort?
The evidence revisited
J Clin Psych, 2004, 65, 611-617
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
14
Linde, K.; Berner, M.; Egger, M.; Mulrow, C.
St John's wort for depression
Meta-analysis of randomised controlled trials
Brit J Psychiatry, 2005, 186, 99-107
St John's wort for depression
Meta-analysis of randomised controlled trials
Brit J Psychiatry, 2005, 186, 99-107
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
15
Knüppel, L.; Linde, K.
Adverse effects of St. John's wort
A systematic review
J Clin Psych, 2004, 65, 1470-1479
Adverse effects of St. John's wort
A systematic review
J Clin Psych, 2004, 65, 1470-1479
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review, Adverse effect
16
Beer, A.-M.; Jackwert, A.; Fey, S.; Darmer, M.
Anwendungsbeobachtung zur Behandlung leichter bis mittelschwerer Depressionen bei weiblichen Patienten durch Lichttherapie bzw. Johanniskrautextrakt
EHK, 2005, 54(11), 719-726
Anwendungsbeobachtung zur Behandlung leichter bis mittelschwerer Depressionen bei weiblichen Patienten durch Lichttherapie bzw. Johanniskrautextrakt
EHK, 2005, 54(11), 719-726
Depression, Assesment, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Light therapy, Non-randomized trial, Physical therapy, Phytomedicine, Mental diseases
17
Pilkington, K.; Boshnakova, A.; Richardson, J.
St. John's wort for depression
Time for a different perspective?
Complement Ther Med, 2006, 14(4), 268-281
St. John's wort for depression
Time for a different perspective?
Complement Ther Med, 2006, 14(4), 268-281
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
18
Ernst, E.
Herbal remedies for depression and anxiety
Adv Psych Treat, 2007, 13, 312-316
Herbal remedies for depression and anxiety
Adv Psych Treat, 2007, 13, 312-316
Anxiety, Crataegus, Depression, Eschscholtzia californica, Ginkgo, Hypericum, St John's wort, Kava, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Matricaria, Matricaria recutita, Melissa, lemon balm, maracuia, Passiflora incarnata, Phytomedicine, Piper, Mental diseases, Systematic review, Valeriana
19
Linde, K.; Berner, M.M.; Kriston, L.
St. John's wort for major depression
Cochrane Database Syst Rev, 2008, 4(CD000448), 1-147
St. John's wort for major depression
Cochrane Database Syst Rev, 2008, 4(CD000448), 1-147
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
20
Rahimi, R.; Nikfar, S.; Abdollahi, M.
Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors
A meta-analysis
Prog Neuropsychopharmacol Biol Psychiatry, 2009, 33(1), 118-127
Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors
A meta-analysis
Prog Neuropsychopharmacol Biol Psychiatry, 2009, 33(1), 118-127
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
21
Sarris, J.; Kavanagh, D.J.
Kava and St. John's Wort
Current evidence for use in mood and anxiety disorders
J Altern Complement Med, 2009, 15(8), 827-836
Kava and St. John's Wort
Current evidence for use in mood and anxiety disorders
J Altern Complement Med, 2009, 15(8), 827-836
Anxiety, Depression, Hypericum, St John's wort, Kava, Clinical research, Complementary and alternative medicine, Phytomedicine, Piper, Mental diseases, Systematic review
22
Wan, H.; Chen, Y.
Effects of antidepressive treatment of Saint John's wort extract related to autonomic nevous function in women with irritable bowel syndrome
Int J Psychiatry Med, 2010, 40(1), 45-56
Effects of antidepressive treatment of Saint John's wort extract related to autonomic nevous function in women with irritable bowel syndrome
Int J Psychiatry Med, 2010, 40(1), 45-56
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Gastrointestinal tract, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases, Irritable bowel syndrome, Vegetative nervous system
23
Dwyer, A.V.; Whitten, D.L.; Hawrelak, J.A.
Herbal medicines, other than St. John's Wort, in the treatment of depression
A systematic review
Altern Med Rev, 2011, 16(1), 40-49
Herbal medicines, other than St. John's Wort, in the treatment of depression
A systematic review
Altern Med Rev, 2011, 16(1), 40-49
Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
24
Honarmand, K.; Tierney, M.C.; O'Connor, P.; Feinstein, A.
Effects of cannabis on cognitive function in patients with multiple sclerosis
Neurology, 2011, 76(13), 1153-1160
Effects of cannabis on cognitive function in patients with multiple sclerosis
Neurology, 2011, 76(13), 1153-1160
Anxiety, Cannabis, Depression, Clinical research, Complementary and alternative medicine, Multiple sclerosis, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases
25
Ulbricht, C.; Chao, W.; Tanguay-Colucci, S.; Conquer, J.; Costa, D.; Culwell, S.; Giese, N.; Higdon, E.R.B.; Isaac, R.; Kaltenbach, M.; Kligler, B.; Laster, R.; Liu, Y.; McCarthy, M.; Nachum, B.; Nummy, K.; Redwanski, J.; Rusie, E.; Windsor, R.; Wojcik, G.J.; Zhou, S.
Rhodiola (Rhodiola spp.)
An evidence-based systematic review by the Natural Standard Research Collaboration
Altern Compl Ther, 2011, 17(2), 110-119
Rhodiola (Rhodiola spp.)
An evidence-based systematic review by the Natural Standard Research Collaboration
Altern Compl Ther, 2011, 17(2), 110-119
Anxiety, Chronic fatigue syndrome, Depression, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Rhodiola, Systematic review
26
Hongratanaworakit, T.
Aroma-therapeutic effects of massage blended essential oils on humans
Nat Prod Commun, 2011, 6(8), 1199-1204
Aroma-therapeutic effects of massage blended essential oils on humans
Nat Prod Commun, 2011, 6(8), 1199-1204
Anxiety, Aromatherapy, Citrus, Citrus bergamia, Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Manual therapy, Massage, Nervous system, Non-randomized trial, Phytomedicine, Placebo-controlled, Mental diseases, Vegetative nervous system
27
Berner, M.M.
Ergebnisse einer aktuellen Metaanalyse
Die Behandlung von Depressionen mit Johanniskraut
NaturaMed, 2009, 24, 1-7
Ergebnisse einer aktuellen Metaanalyse
Die Behandlung von Depressionen mit Johanniskraut
NaturaMed, 2009, 24, 1-7
Depression, Hypericum, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
28
Kasper, S.; Dienel, A.
Silexan (WS 1265) vermindert begleitende depressive Symptome bei Patienten mit Angsterkrankungen
Z Phytother, 2013, 34(Suppl. 1), s8 (Abstract; Symposiumsbeitrag)
Silexan (WS 1265) vermindert begleitende depressive Symptome bei Patienten mit Angsterkrankungen
Z Phytother, 2013, 34(Suppl. 1), s8 (Abstract; Symposiumsbeitrag)
Anxiety, Concomitant symptoms, Depression, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Meta-analysis, Phytomedicine, Placebo-controlled, Mental diseases
29
Kelber, O. ; Müller, J.; Okpanyi, S.N.
Die Entzündungshypothese der Depression
Johanniskraut als therapeutischer Ansatz?
Z Phytother, 2013, 34(Suppl.1), s28-s29 (Abstract, Symposiumsbeitrag)
Die Entzündungshypothese der Depression
Johanniskraut als therapeutischer Ansatz?
Z Phytother, 2013, 34(Suppl.1), s28-s29 (Abstract, Symposiumsbeitrag)
Depression, Inflammation, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
30
Hausenblas, H.A.; Saha, D.; Dubyak, P.J.; Anton, S.D.
Saffron (Crocus sativus L.) and major depressive disorder
A meta-analysis of randomized clinical trials
J Integr Med, 2013, 11(6), 377-383
Saffron (Crocus sativus L.) and major depressive disorder
A meta-analysis of randomized clinical trials
J Integr Med, 2013, 11(6), 377-383
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
31
Liu, L.-Y.; Feng, B.; Chen, J.; Tan, Q.-R.; Chen, Z.-X.; Chen, W.-S.; Wang, P.-R.; Zhang, Z.-J.
Herbal medicine for hospitalized patients with severe depressive episode
A retrospective controlled study
J Affect Disord, 2015, 170, 71-77
Herbal medicine for hospitalized patients with severe depressive episode
A retrospective controlled study
J Affect Disord, 2015, 170, 71-77
Depression, Clinical research, Complementary and alternative medicine, Hospital, Non-randomized trial, Phytomedicine, Practice, Mental diseases, Retrospective design
32
Tang, S.K.; Tse, M.Y.M.
Aromatherapy: Does it help to relieve pain, depression, anxiety, and stress in community-dwelling older persons?
Biomed Res Int, 2014, Article ID 430195, (1-12)
Aromatherapy: Does it help to relieve pain, depression, anxiety, and stress in community-dwelling older persons?
Biomed Res Int, 2014, Article ID 430195, (1-12)
Anxiety, Applikationsform, Aromatherapy, Citrus, Citrus bergamia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Lavendula, Lavendula angustifolia, Non-randomized trial, Phytomedicine, Mental diseases, Pain, Stress, Inhalation
33
Al-Karawi, D.; Al Mamoori, D.A.; Tayyar, Y.
The role of curcumin administration in patients with major depressive disorder
Mini meta-analysis of clinical trials
Phytother Res, 2016, 30(2), 175-183
The role of curcumin administration in patients with major depressive disorder
Mini meta-analysis of clinical trials
Phytother Res, 2016, 30(2), 175-183
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
34
Prichard, C.; Newcomb, P.
Benefit to family members of delivering hand massage with essential oils to critically ill patients
Am J Crit Care, 2015, 24(5), 446-449
Benefit to family members of delivering hand massage with essential oils to critically ill patients
Am J Crit Care, 2015, 24(5), 446-449
Anxiety, Aromatherapy, Citrus, Citrus bergamia, Depression, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Non-randomized trial, Phytomedicine, Mental diseases, Intensivmedizin
35
Kim, H.S.; Kim, S.H.; Park, Y.S.; Kim, M.Y.
The effects of aroma massage and regular oil hand massage on the blood cortisol and serotonin level of elderly
Int J Bio Sci Bio Technol, 2016, 8(3), 119-126
The effects of aroma massage and regular oil hand massage on the blood cortisol and serotonin level of elderly
Int J Bio Sci Bio Technol, 2016, 8(3), 119-126
Anxiety, Aromatherapy, Depression, Endocrinology, Geriatrics, Clinical research, Complementary and alternative medicine, Non-randomized trial, Phytomedicine, Mental diseases, Serotonin, Cortisol
36
Apaydin, E.A.; Maher, A.r.; Shanman, R.; Booth, M.S.; Miles, J.N.V.; Sorbero, M.E.; Hempel, S.
A systematic review of St. John’s wort for major depressive disorder
Syst Rev, 2016, 5, 148; (1-25)
A systematic review of St. John’s wort for major depressive disorder
Syst Rev, 2016, 5, 148; (1-25)
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Phytomedicine, Mental diseases, Systematic review
37
Ng, Q.X.; Venkatanarayanan, N.; Ho, C.Y.
Clinical use of Hypericum perforatum (St John's wort) in depression
A meta-analysis
J Affect Disord, 2017, 210, 211-221
Clinical use of Hypericum perforatum (St John's wort) in depression
A meta-analysis
J Affect Disord, 2017, 210, 211-221
Depression, Hypericum, St John's wort, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
38
Yang, Y.P.; Lee, F.P.; Chao, H.C.; Hsu, F.Y.; Wang, J.J.
Comparing the effects of cognitive stimulation, reminiscence, and aroma-massage on agitation and depressive mood in people with dementia
J Am Med Dir Assoc, 2016, 17(8), 719-724
Comparing the effects of cognitive stimulation, reminiscence, and aroma-massage on agitation and depressive mood in people with dementia
J Am Med Dir Assoc, 2016, 17(8), 719-724
Aromatherapy, Dementia, Depression, Geriatrics, Clinical research, Complementary and alternative medicine, Manual therapy, Massage, Nervous system, Non-randomized trial, Phytomedicine, Mental diseases
39
Yeung, K.S.; Hernandez, M.; Mao, J.J.; Haviland, I.; Gubili, J.
Herbal medicine for depression and anxiety
A systematic review with assessment of potential psycho-oncologic relevance
Phytother Res, 2018, 32(5), 865-891
Herbal medicine for depression and anxiety
A systematic review with assessment of potential psycho-oncologic relevance
Phytother Res, 2018, 32(5), 865-891
Anxiety, Depression, Clinical research, Complementary and alternative medicine, Cancer, Phytomedicine, Mental diseases, Systematic review
40
Ng, Q.X.; Koh, S.S.H.; Chan, H.W.; Ho, C.Y.X.
Clinical use of curcumin in depression
A meta-analysis
J Am Med Dir Assoc, 2017, 18(6), 503-508
Clinical use of curcumin in depression
A meta-analysis
J Am Med Dir Assoc, 2017, 18(6), 503-508
Curcuma, Curcuma longa, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
41
Yang, X.; Chen, X.; Fu, Y.; Luo, Q.; Du, L.; Qiu, H.; Qiu, T.; Zhang, L.; Meng, H.
Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults
A meta-analysis of randomized controlled trials
Neuropsychiatr Dis Treat, 2018, 14, 1297-1305
Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults
A meta-analysis of randomized controlled trials
Neuropsychiatr Dis Treat, 2018, 14, 1297-1305
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
42
Tóth, B.; Hegyi, P.; Lantos, T.; Szakács, Z.; Kerémi, B.; Varga, G.; Tenk, J.; Pétervári, E.; Balaskó, M.; Rumbus, Z.; Rakonczay, Z.; Bálint, E.R.; Kiss, T.; Csupor, D.
The efficacy of saffron in the treatment of mild to moderate depression
A meta-analysis
Planta Med, 2019, 85(1), 24-31
The efficacy of saffron in the treatment of mild to moderate depression
A meta-analysis
Planta Med, 2019, 85(1), 24-31
Crocus, Depression, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases
43
Su, B.Y.; Tung, T.H.; Chien, W.H.
Effects of phytoestrogens on depressive symptoms in climacteric women
A meta-analysis of randomized controlled trials
J Altern Complement Med, 2018, 24(8), 850-851 (Letter)
Effects of phytoestrogens on depressive symptoms in climacteric women
A meta-analysis of randomized controlled trials
J Altern Complement Med, 2018, 24(8), 850-851 (Letter)
Depression, Gynaecology, Climacteric, Clinical research, Complementary and alternative medicine, Meta-analysis, Phytomedicine, Mental diseases, Systematic review
Abstract:
http://dx.doi.org/10.1089/acm.2017.0118
44
Zwanzger, P.; Wacker, A.
Silexan bei somatischen Angstsymptomen
Z Phytother, 2017, 38 (Suppl.1), 44 (Abstract (Poster))
Silexan bei somatischen Angstsymptomen
Z Phytother, 2017, 38 (Suppl.1), 44 (Abstract (Poster))
Anxiety, Depression, Ear-nose-throat disorders, Clinical research, Complementary and alternative medicine, Meta-analysis, Ear noises, Phytomedicine, Mental diseases, Silexan